Endocrine Abstracts

: A large number of studies are now focused on the causes of male infertility. Among these are epigenetic modifications, which are important contributors to reproductive pathology in the male by providing dynamic changes of the phenotype according to the environmental and metabolic factors. The most known epigenetic modification is DNA methylation and alterations in this pattern in several genes could induce male infertility. Alterations in DNA methylation patterns in several ...

The CDX2 VDR polymorphism (rs11568820) is located in the promoter region of exon 1 in the 5′-untranslated region of the VDR gene.Objective: The current investigation examines the association between CDX2 VDR polymorphism and male infertility.Subjects and methods: The study was conducted on 69 infertile men, aged between 20 and 50 years, divided into three groups, based on spermatic parameters: group with azoospermia (19 subje...

Only a few genes involved in spermatogenesis have clinical importance: Y chromosome micro deletions in the region called azoospermia factor (AZF) and oestrogen receptor alpha gene polymorphisms (ESR1).Objective: The study aim to evaluate ESR1 and Y chromosome deletion in infertile men.Subjects and methods: 43 infertile men, and 34 fertile men aged 20–50 years 50, were enrolled after signing the informed consent. Screening for ...

Vitamin D (VD) now considered a steroid hormone, has been correlated with male reproductive disorders. The activity of VD is mediated through its receptor (VDR), distributed in various tissues including reproductive tissues. VDR polymorphism located in the promoter region of the gene, rs17883968 (Cdx2) G → A associated with transcriptional activity. The aim of this study was to assess both seminal and serum VD levels in a group of infertile patients (n=87, media...

Introduction: The deregulation in miRNA expression has been described in thyroid tumors, and is considered an important factor in thyroid carcinogenesis. mRNA expression profiling in cancer allows identifications of signatures associated with diagnosis, staging, prognosis, and response to treatment.Objective: We aimed to detect miRNAs species differentially expressed between tumor and peritumoral tissue in papillary thyroid carcinoma.<p class="abstex...

Introduction: HOXB4 functions as a transcription factor involved in cell differentiation during embryogenesis and plays a role in apoptosis.Aim: This study analyzed HOXB4 methylation status in thyroid papillary carcinoma.Method: 54 patients aged 10–82 years hospitalized for thyroidectomy were included between January 2013 and July 2013. The inclusion criterion was patients with thyroid nodules with indication for surgery and t...

Male infertility arises as a global public health in the context of the dramatic decrease in birth rates, within a complex picture of hormonal, genetic and epigenetic factors. However, the underlying causes of male infertility remain unknown in many cases. Our study included samples (n = 82, median: 34 years, range 20–55 years) obtained from men investigating couple infertility and from a normal control group (n = 11, median: 29 years, range 21–55 y...